OBJECTIVE To investigate the pharmacokinetics of flupirtine maleate in Chinese Han nationality healthy volunteers. METHODS 10 Healthy volunteers were given with a single oral dose (100 mg of flupirtine maleate capsule. Blood samples were collected from vein at certain sampling times. Flupirtine maleate in plasma were determined by HPLC fluorescence method，and the pharmacokinetic parameters were calculated by 3P97 software. RESULTS The plasma concentration-time curves of flupirtine were discribed by a two-compartment model with first order absorption. The main pharmacokinetic parameters were as follows： t_max (1.70±0.79 h， ρ_max (1 078.1±296.7 μg·L-1， t_1/2α（1.46±0.51h，t_1/2β（9.37±2.57h and AUC_0-∞（8 971.7±1 996.5μg·h·L-1. CONCLUSION The pharmacokinetic parameters of flupirtine maleate in healthy volunteers after an oral single dose of flupirtine maleate capsule is concordant with that of the literature.