Anti-tumor Effect of Albumin-Paclitaxel Polymeric Micelle

SUN Min-min;HO Yn-li;TI Wen;LIU Nn;M Ming-shu;YIN Zhe;NIE Shng-hi;ZHNG Xio-ning

Chinese Pharmaceutical Journal ›› 2011, Vol. 46 ›› Issue (3) : 199-202.

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Chinese Pharmaceutical Journal ›› 2011, Vol. 46 ›› Issue (3) : 199-202.

Anti-tumor Effect of Albumin-Paclitaxel Polymeric Micelle

  • SUN Min-min1，HAO Yan-li1，TAI Wen1，LIU Nan1，MA Ming-shu1，YIN Zhe1， NIE Shang-hai2， ZHANG Xiao-ning1*
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Abstract

OBJECTIVE To develop paclitaxel polymeric micelle(PTX PM and albumin-paclitaxel polymeric micelle（HSA-PTX PM，to evaluate the anti-tumor activity of two formulations and the PTX injection sold in market. METHODS The particle size and morphology of PTX PM and HSA-PTX PM were analyzed by ZetePALS Zeta Potential Analyzer and Transmission Electron Microscope. The anti-tumor activity was determined by traditional method and in vivo imaging technique method. The effect of two formulations on life span of B16 tumor-bearing mice was investigated by the B16 tumor-bearing mouse model . RESULTS The size distributions of PTX PM and HSA-PTX PM were similar. The effective diameters of two formulations were both around 100 nm. The appearance of the particle was spherical. In vivo imaging pictures showed HSA-PTX PM and PTX PM obtained better anti-tumor effect than the PTX injection and HSA-PTX PM was best. HSA-PTX PM with the inhibition rate of 72.92% was better than PTX PM（66.49%and PTX injection（47.68%（P<0.05.The results were similar to the traditional method. HSA-PTX PM prolonged the mean life span of B16 tumor-bearing mouse compared with PTX injection. CONCLUSION The anti-tumor activities of PTX PM and HSA-PTX PM was better than PTX injection while HSA-PTX PM was the best. The technology using the drug carrier albumin together with polymeric micelle has a wonderful prospect.

Key words

albumin / polymeric micelle / in vivo imaging / anti-tumor effect / paclitaxel

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SUN Min-min;HO Yn-li;TI Wen;LIU Nn;M Ming-shu;YIN Zhe;NIE Shng-hi;ZHNG Xio-ning. Anti-tumor Effect of Albumin-Paclitaxel Polymeric Micelle[J]. Chinese Pharmaceutical Journal, 2011, 46(3): 199-202

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