Study on the Intestinal Absorption Kinetics of Schizonepetin in Rats

GENG Ting;ZHU Hui;DING n-wei;ZHNG Li

Chinese Pharmaceutical Journal ›› 2011, Vol. 46 ›› Issue (24) : 1911-1914.

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PDF(738 KB)
Chinese Pharmaceutical Journal ›› 2011, Vol. 46 ›› Issue (24) : 1911-1914.

Study on the Intestinal Absorption Kinetics of Schizonepetin in Rats

  • GENG Ting1, ZHU Hui1, DING An-wei1,2, ZHANG Li1
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Abstract

OBJECTIVE To investigate the absorption kinetics of schizonepetin in intestines of rats. METHODS In situ recirculation model was established in rats. The volume of recirculation fluid was adjusted by phenol red. The contents of schizonepetin at different point time were detected by HPLC. RESULTS The absorption rate constant (Ka) of schizonepetin at low, middle and high concentrations (1.84, 3.68 and 7.36 μg·mL-1) were (0.202 8±0.007 0), (0.158 9±0.011 4) and (0.134 2±0.012 2) h-1, respectively, showing significant differences (P<0.05). The Ka of schizonepetin at concentration of 3.68 μg·mL-1 at duodenum, jejunum and ileum were (0.023 8±0.000 6), (0.012 5±0.000 5) and (0.016 5±0.000 8) h-1, respectively (P<0.05). Bile duct ligation and intestinal flora had little influence on the intestinal absorption of schizonepetin. The Ka of P-gp inhibitor group had significant difference with that of the control group (P<0.05). CONCLUSION The absorption of schizonepetin follows first-order process with active diffusion mechanism. Schizonepetin can be absorbed at all intestinal segments, and duodenum is the best absorption site.

Key words

schizonepetin / in situ recirculation / absorption kinetics / HPLC

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GENG Ting;ZHU Hui;DING n-wei;ZHNG Li. Study on the Intestinal Absorption Kinetics of Schizonepetin in Rats[J]. Chinese Pharmaceutical Journal, 2011, 46(24): 1911-1914

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