Effect of Asterias amurensis Polysaccharides on Immune Function of Normal Mice
LIU Tie-zheng， GUO Ai-jie， WANG Gui-chun， WU Ze-hua， CHU Fu-long， ZHANG Chong-xi*
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Marine College， Shandong University， Weihai 264209， China
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Received
Revised
Published
2011-11-11
2011-11-11
2011-12-15
Issue Date
2011-12-15
Abstract
OBJECTIVE To study the effect of Asterias amurensis polysaccharides (AAP) on immune function of normal mice. METHODS The mice were treated with oral administration of AAP (50， 100， 200 mg·kg-1) for 14 d. The effect of AAP on immune organs was evaluated by determination of immune organ indexes. By determining the count and phagocytic activity of leucocytes in blood and lysozyme (LZM) content in serum， the effect of AAP on nonspecific immunity was studied. By determining the content of glutathione (GSH) in liver cells， detoxification capability of liver was investigated. Lymphocyte proliferation test was adopted to assess the effect of AAP on cellular immunity. RESULTS Compared with the control group， AAP increased immune organ indexes， phagocytic activity of leucocytes in blood， content of LZM in serum and content of GSH in liver cells， but had no effect on leucocyte count. The effect of AAP on multiplication capacity of lymphocytes was significant. CONCLUSION APP can stimulate the nonspecific immunity and cellular immunity in normal mice.
LIU Tie-zheng;GUO i-jie;WNG Gui-chun;WU Ze-hu;CHU Fu-long;ZHNG Chong-xi.
Effect of Asterias amurensis Polysaccharides on Immune Function of Normal Mice[J]. Chinese Pharmaceutical Journal, 2011, 46(24): 1894-1897
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References
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