Effect of Conbinated of General Anesthesia and Epidural Anesthesia on Early Postoperative cognitive Dysfunction in Eder
YU Jie， QI Xue-fen
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Department of anesthesiology， Kecheng district people hospital， Quzhou 324000， China
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Received
Revised
Published
2011-11-11
2011-11-11
2011-08-15
Issue Date
2011-08-15
Abstract
OBJECTIVE To compare the effects of genera1 anesthesia versus combined epidural and general anesthesia on early postoperative cognitive dysfunction(POCD) in elderlies. METHODS Sixty patients aged 70-88 years, scheduled for elective upper abdominal surgery with ASA Ⅰ-Ⅲ, were randomly divided into general anesthesia group(group G, n=27) and combined epidural and genera1 anesthesia group(group C, n=28), and received genera1 anesthesia with tracheal intubation and thoracic epidural blockade with 0.375% ropivacaine, , respectively. POCD was assessed by mini-metal state examination(MMSE) and serum S100β levels at 24 h before operation, 1, 3 and 5 d after operation respectively. Z value was used to analyze the data. POCD was defined as Z value ≥ 2. RESULTS There was no significant difference between the preoperative MMSE and serum S100β levels of the the two groups. At 1 d after surgery, POCD incidences were 16(59.2%) in group G and 10(35.7 %) in group C(P<0.05). At 3 d after surgery, POCD was present in 9(33.3%) in group G and 6(21.2%) in group C(P<0.05). CONCLUSION When applied to major abdominal surgery, combined general anesthesia and thoracic epidural blockade can decrease POCD incidence and serum S100β levels compared with general anesthesia.
YU Jie;QI Xue-fen.
Effect of Conbinated of General Anesthesia and Epidural Anesthesia on Early Postoperative cognitive Dysfunction in Eder[J]. Chinese Pharmaceutical Journal, 2011, 46(16): 1286-1288
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References
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