Mechanical Properties of Film from Acrylic Polymer Eudragdit EPO
ZHANG Xiao-hong1, CAO Xin-ke2,3, LI Yi-qun2,CHEN Dong2,DING Ping-tian2*
Author information+
1.Chinese Pharmacopoeia Commission, Beijing 100061,China; 2.School of Pharmacy,Shenyang Pharmaceutical University,Shenyang 110016,China; 3. Institute of Biopharmaceuticals of Shandong Province, Jinan 250108,China
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History+
Received
Revised
Published
2012-01-01
2012-01-01
2012-01-01
Issue Date
2010-01-15
Abstract
OBJECTIVE To study the mechanical properties of film from acrylic polymer Eudragdit EPO which was prepared by a casting method. METHODS Tensile testing was used to determine tensile strength(σ), tensile strain at break (ε) and modulus of elasticity of the film(E). The ratio of tensile strength to tensile strain at break(σ/E), relative surface energy (σ2/2E), work at break(W) were calculated. RESULTS Parameters as σ,ε,E, σ/E, σ2/2E and W was used to evaluate mechanical properties of film from acrylic polymer Eudragdit EPO.CONCLUSION The drying temperature, film thickness and concentration of plasticizer affected the mechanical properties of film significantly, while the film-formation time did not. The study might be helpful for coating process and formulation screen.
ZHNG Xio-hong;CO Xin-ke;LI Yi-qun;CHEN Dong;DING Ping-tin.
Mechanical Properties of Film from Acrylic Polymer Eudragdit EPO[J]. Chinese Pharmaceutical Journal, 2010, 45(2): 128-131
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References
[1] ZHENG J M. The Process and Mechanism of Tablets Coating(片剂的包衣工艺和原理)[M]. Beijing: Chinese Medical Science and Technology Press,2001:283-284. [2] PARIKH N H, PORTER S C, ROHERA B D. Tensile properties of free films cast from Aqueous Ethylcellulose Dispersions[J]. Pharm Res,1993, 10(6):810-815. [3] FROHOFF-ZHULSMANN M A, LIPPOLD B C, MCGINITY J W. Aqueous ethyl cellulose dispersions containing plasticizers of different water solubility and hydroxypropyl methyl-cellulose as coating material for diffusion pellets:ⅡProperties of sprayed films[J]. Eur J Pharm Biopharm,1999, 48(1):67-75. [4] ZHANG L C,HU J H,LI Z, et al. Mechanical properties and permeability of controlled-release films prepared by different techniques [J].Chin J Pharm(中国医药工业杂志),2002,33(1):19-22. [5] HYPPOLA R, HUSSON I, SUNDHOLM F. Evaluation of physical properties of plasticized ethyl cellulose films cast from ethanol solution PartⅠ[J].Int J Pharm, 1996,133(1-2):161-170. [6] ROWE R C. A reappraisal of the equations used to predict the internal stresses of film coatings applied to tablet substrates[J]. Pharm Pharmacol, 1983,35(2): 112-113. [7] OKHAMZAFE A O, YORK P. Stress crack resistance of some pigmented and unpigmented tablet film coating systems[J].Pharm Pharmacol, 1985, 37(7):449-454. [8] ZHANG L C,HU J H,LI Z,et al. Optimization of plasticizers in free coating membranes of osmotic acrylic resin Eudragit RS 100[J]. Acta Pharm Sin(药学学报),2001,36(12):937-941. [9] GOODHART F W, HARRIS M R. An evaluation of aqueous film-forming dispersions for controlled release[J].Pharm Technol, 1984, 8(4): 64-71.