Influence Factors on the Release of the Main Active Composition of Saussurea involucrate from Gel Sustained-Release Matrix Tablets

XING Jin-guo;WNG Xin-chun;LIU Gui-hu;XUE Gui-peng

Chinese Pharmaceutical Journal ›› 2010, Vol. 45 ›› Issue (12) : 913-917.

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PDF(2039 KB)
Chinese Pharmaceutical Journal ›› 2010, Vol. 45 ›› Issue (12) : 913-917.

Influence Factors on the Release of the Main Active Composition of Saussurea involucrate from Gel Sustained-Release Matrix Tablets

  • XING Jian-guo1， WANG Xin-chun2，3*，LIU Gui-hua2， XUE Gui-peng1
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Abstract

OBJECTIVE To prepare Saussurea involucrate sustained- release tablets and to study influence factors on release of the main active composition of Saussurea involucrate.METHODS The Saussurea involucrate sustained-release tablets was compressed after wet granulating the extracts of Saussurea involucrate with HPMC. Then， the influence factors on release of two main active composition of Saussurea involucrate were investigated by determining release rate of chlorogenic acid and rutin at different time to draw release curve and to calculate K（index which was comprehended with cumulative release at 2，6，12 h， respectively）and f 2 ( similar factor of release curve). RESULTS The main influence factors on release rate of two main active composition of Saussurea involucrate were viscosity of HPMC and amount of used starch. The particle diameter of HPMC， adhesive and pressure show no effect on release.The later release amounts of two main active composition were increased by MCC. CONCLUSION The release of two main active composition of Saussurea involucrate could be controlled effectively by selecting HPMC K15M as matrices.

Key words

Saussurea involucrate / HPMC / matrices / in vitro dsissolution

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XING Jin-guo;WNG Xin-chun;LIU Gui-hu;XUE Gui-peng. Influence Factors on the Release of the Main Active Composition of Saussurea involucrate from Gel Sustained-Release Matrix Tablets[J]. Chinese Pharmaceutical Journal, 2010, 45(12): 913-917

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