Effect of Different Administrations of Yuchangning on Ulcerative Colitis in Rats Induced by TNBS

XIE Xing-ling;SHENG Yn-mei;ZENG Min;YNG Ming

Chinese Pharmaceutical Journal ›› 2010, Vol. 45 ›› Issue (12) : 906-908.

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Chinese Pharmaceutical Journal ›› 2010, Vol. 45 ›› Issue (12) : 906-908.

Effect of Different Administrations of Yuchangning on Ulcerative Colitis in Rats Induced by TNBS

  • XIE Xing-liang1， SHENG Yan-mei1， ZENG Min2， YANG Ming2*
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Abstract

OBJECTIVE To evaluate administration route of Yuchangning to treat ulcerative colitis（UC）by the pharmacodynamics， and to provide a scientific basis for the design on praeparatum. METHODS UC was induced in rat trinitro-benzene-sulfonic acid（TNBS）. Yuchangning was given to rats by intragastric administration (Ⅰ) ， coloclysis administration (Ⅱ)， and composition of radix astragali in intragastric administration plus composition of radix sophorae flavescentis in coloclysis (Ⅲ). The change of morphous of tunica mucosa coli was observed. The coefficient of colon weight，concentration of TNF-α in serum and MPO in tunica mucosa coli was measured. RESULTS Compared with the model group， both group Ⅱand Ⅲ improved the injury of tunica mucosa coli，decreased coefficient of colon weight（P<0.05，P<0.01），decrease the level of MPO and TNF-α（P<0.01）. RouteⅠ only decreased the level of TNF-α. CONCLUSION Among the three administration ways， Ⅲ is the best，which provides the experimental basis for the design on praeparatum of Yuchangning.

Key words

Yuchangning / administration way / ulcerative colitis / comparision of pharmacological action

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XIE Xing-ling;SHENG Yn-mei;ZENG Min;YNG Ming. Effect of Different Administrations of Yuchangning on Ulcerative Colitis in Rats Induced by TNBS[J]. Chinese Pharmaceutical Journal, 2010, 45(12): 906-908

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