OBJECTIVE To synthesize curcumin-selenium compound and investigate its antitumor activities in vitro. METHODS A novel organoselenium was synthesized from curcumin and SeOCl2. The content of selenium was determined by hydride generator atomic absorb spectrometry. The structure of new compound was confirmed by UV,IR,MS,1H-NMR and 13C-NMR spectral data. The cytotoxicity activities in vitro were evaluated against seven human cancer cell lines including BGC823, CNE, HL-60, KB, LS174T, PC-3 and HELA by MTT assay. Curcumin and cisplatin were used for comparative purpose. RESULTS The structure of the compound was confirmed as a new curcumin-selenium complex. The IC50 of the new compound on BGC823, CNE, HL-60, KB, LS174T, PC3 and HELA were 45.71，>100，30.09，3.18，>100，21.76 and 2.54 mg·L-1 respectively. The new compound showed inhibition function on KB and HELA cells. CONCLUSION A new curcumin-selenium compound was synthesized for the first time and showed effective potential antitumor activities. It is worthy of further investigation.
Key words
synthesis /
curcumin /
selenium /
antitumor activity
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References
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（ 收稿日期 ： 2009-02-09 ）
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