Study on Partition of Hydroxycamptothecin in the Phases of Liposome and Water

SUO Xu-in;LI Mu-ling;WNG Yu-qing;QIU Jin-she

Chinese Pharmaceutical Journal ›› 2009, Vol. 44 ›› Issue (23) : 1796-1800.

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Chinese Pharmaceutical Journal ›› 2009, Vol. 44 ›› Issue (23) : 1796-1800.
Article

Study on Partition of Hydroxycamptothecin in the Phases of Liposome and Water

  • SUO Xu-bin1,2 ， LI Mu-ling2 ， WANG Yu-qiang2 ， QIU Jian-she3*
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Abstract

OBJECTIVE To determine the partition of hydroxycamptothecin in the phases of liposome and water and to evaluate the influence on the partition coefficients and binding Gibbs energy between the molecules of drug and water. METHODS ■Equilibrium dialysis technique was used to study the liposome/water partition coefficients of drug. The properties of liposome membrane (lipid species and the ratios of cholesterol), pH and ionic strength of medium were studied. The binding Gibbs energy (ΔG) was calculated according to the slope rate of the curve of lnKapp against 1/T. RESULTS The partition of drug in the phases of liposome and water decreased with the increase of membrane rigidity and pH of medium (when pH 4.0), while ionic strength showed the opposite effect on the partition. The binding Gibbs energy (ΔG) of the molecules of drug and liposome membrane was -11.698 kJ·mol-1. CONCLUSION The partition of hydroxycamptothecin in liposome and water may be influenced by the liposome membrane, pH and ionic strength of the medium.

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hydroxycamptothecin / liposome/water / partition

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SUO Xu-in;LI Mu-ling;WNG Yu-qing;QIU Jin-she . Study on Partition of Hydroxycamptothecin in the Phases of Liposome and Water[J]. Chinese Pharmaceutical Journal, 2009, 44(23): 1796-1800

References


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（ 收稿日期 ： 2009-06-24 ）

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