An Adenosine A 2A Receptor Agonist CGS21680 Mimic s Prostaglandin D2 to Induce Physiological Sleep in Rats

LIU W ei;HUNG Z hi- l i;QU W ei- m in

Chinese Pharmaceutical Journal ›› 2009, Vol. 44 ›› Issue (23) : 1786-1790.

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PDF(3152 KB)
Chinese Pharmaceutical Journal ›› 2009, Vol. 44 ›› Issue (23) : 1786-1790.
Article

An Adenosine A 2A Receptor Agonist CGS21680 Mimic s Prostaglandin D2 to Induce Physiological Sleep in Rats

  • LIU W eia, HUANG Z hi- l ia,b, QU W ei- m inb*
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Abstract

OBJECTIVE To compare the sleep-wake profiles induced by endogenous prostaglandin (PG)D2 and CGS21680, an adenosine A2A receptor agonist. METHODS Under 10% chloral hydrate anesthesia [360 mg·kg-1 intraperitoneal (i.p.)], rats underwent the surgery for implantation of electrodes for electroencephalogram (EEG) and electromyogram recordings and placement of a stainless steel cannula inserted stereotaxically into the subarachnoid space under the basal forebrain for infusion of PGD2 or CGS21680. The software SleepSign was used to analyze EEG parameters, including sleep amount, sleep episode, stage transition and power density. RESULTS PGD2 and CGS21680 induced non-rapid eye movement sleep was similar to physiological sleep with the same amounts, identical patterns of sleep episode number and duration, stage transition, and power density. CONCLUSION Activation of adenosine A2A receptors by CGS21680 mimicked the somnogenic effects of PGD2.

Key words

adenosine A2A receptor / CGS21680 / electroencephalogram / prostaglandin D2 / rat / sleep

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LIU W ei;HUNG Z hi- l i;QU W ei- m in . An Adenosine A 2A Receptor Agonist CGS21680 Mimic s Prostaglandin D2 to Induce Physiological Sleep in Rats[J]. Chinese Pharmaceutical Journal, 2009, 44(23): 1786-1790

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（ 收稿日期 ： 2009-01-23 ）

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