OBJECTIVE To study the chemical constituents of Schisandra neglecta. METHODS The chemical constituents were isolated by silica gel , prep-HPLC and prep-TLC methods. And their structures were elucidated by physical-chemical and spectroscopic methods. RESULTS Nine dibenzocyclooctadiene lignans, acetylgomisin R (Ⅰ), schisanhenol B (Ⅱ), (-)-gomisin L1 (Ⅲ), benzoylgomisin P (Ⅳ), tigloylgomisin P (Ⅴ), gomisin R (Ⅵ), kadsurin (Ⅶ), epigomisin O (Ⅸ), gomisin O (Ⅹ)and one kadsuric acid(Ⅷ) were isolated from the stem of S. neglecta. CONCLUSION All compounds were isolated from the plant for the first time.
Key words
Schisandra neglecta /
chemical constituents /
lignan /
triterpene acid
{{custom_keyword}} /
{{custom_sec.title}}
{{custom_sec.title}}
{{custom_sec.content}}
References
[1] CHEN Y G, WANG P, LIN Z W, et al. Dibenzocyclooctadiene lignans from Kadsura angustifolia [J]. Phytochemistry, 1998, 48(6):1059-1062.
[2] CHEN D F, ZHANG S X, CHEN K, et al. Two new lignans , interiotherins A and B , as anti-HIV principles from Kadsura interior [J ] . J Nat Prod, 1996 , 59(11):1066-1068.
[3] KUO Y H, KUO L M, CHEN C F. Four new C19 homolignans, schiarisanrins A, B and D and cytotoxic schiarisanrin C from <>Schizandra arisanensis[J]. J Org Chem, 1997, 62(10): 3242-3245.
[4] Institutum Botanicum Kunmingense Academiae Sinicae Edita.<>Flors Yunaecnica( 云南植物志 ) [M]. Beijing : Science Press, 2000.
[5] CHEN Y G, QIN G W, XIE Y Y. Dibenzocyclooctadiene lignans from schisand a propinqua [J] . Chem J Chin Univ ( 高等学校化学学报 ), 2001, 22(9):1518-1520.
[6] IKEYA Y, MIKI E, OKADA M, et al. Benzoylgomisin Q and P, two new lignans from Schisandra <>sphenanthera Rehd. Et Wils. [J]. Chem Pharm Bull, 1990, 38(5):1408-1411.
[7] IKEYA Y, TAGUCHI H, YOSIOKA I. The constituents of schizandra chinensis baill. Ⅹ. The sturctures of γ-schizandrin and four new lignans, (-)-gomisins L1 and L2, (±)-gomisin M1 and (+)-gomisin M2[J]. Chem Pharm Bull, 1982, 30(1):132-139.
[8] IKEYA Y, TAGUCHI H, YOSIOKA I. The constituents of schizandra chinensis baill XII. isolation and structure of a new lignan, gomisin R, the absolute structure of Wuweizisu C and isolation of schisantherin D [J]. Chem Pharm Bull, 1982, 30(9):3207-3211.
[9] CHEN D F, XU G J, YANG X W. et al. Dibenzocyclo-octadiene lignans from Kadsura <>heteroclite [J]. Phytochemistry,1992, 31(2):629-632.
[10] YAMADA Y, HSU C S, IGUCHI K, et al. Structure of kadsuric acid. A new seco-triterpenoid from Kadsura <>japonica Dunal [J]. Chem Lett , 1976, 1307-1310.
[11] IKEYA Y, TAGUCHI H, YOSIOKA I. et al . The constituents of schizandra chinensis baill. Ⅴ. The strutures of four new lignans, gomisin N, gomisin O, epigomisin O and gomisin E, and transformation of gomisin N to deangeloylgomisin B [J]. Chem Pharm Bull, 1979, 27(11):2695-2709.
（ 收稿日期 ： 2009-04-07 ）
{{custom_fnGroup.title_en}}
Footnotes
{{custom_fn.content}}
PDF(2682 KB)
