Protective Effects of 20(<>R)-Ginsenoside Rg 3 on Human Umbilical Vein Endothelial Cell Injury Induced by LPS

HE o;CHEN Peng;YNG Li;ZHNG Xio-cho;JI Fng;SHEN Zhi-qing

Chinese Pharmaceutical Journal ›› 2009, Vol. 44 ›› Issue (22) : 1703-1707.

PDF(2589 KB)
PDF(2589 KB)
Chinese Pharmaceutical Journal ›› 2009, Vol. 44 ›› Issue (22) : 1703-1707.
Article

Protective Effects of 20(<>R)-Ginsenoside Rg 3 on Human Umbilical Vein Endothelial Cell Injury Induced by LPS

  • HE Bo, CHEN Peng , YANG Li, ZHANG Xiao-chao , JI Fang , SHEN Zhi-qiang *
Author information +
History +

Abstract

Cite this article

Download Citations
HE o;CHEN Peng;YNG Li;ZHNG Xio-cho;JI Fng;SHEN Zhi-qing . Protective Effects of 20(<>R)-Ginsenoside Rg 3 on Human Umbilical Vein Endothelial Cell Injury Induced by LPS[J]. Chinese Pharmaceutical Journal, 2009, 44(22): 1703-1707

References


[1] CHUDEK J, WIECEK A. Adipose tissue, inflammation and endothelial dysfunction [J] . Pharmacol Rep , 2006 , 58(Suppl 1): 81-88.
[ 2] ROSS R. The pathogenesis of atherosclerosis: a perspective for the 1990's [ J] . Nature, 1993 , 362(6423) : 801-809 .
[ 3] FU J, WANG H Y, QU P. Effect of GBE50 on LPS- induced LOX-1 expression in HUVECs [ J] . J Dalian Med Univ ( 大连医科大学学报 ) , 2006 , 28 ( 5 ): 378-380.
[ 4] XIE H T, WANG G J , SUN J G . High performance liquid chromatographic-ass spectrometric determination of ginsenoside Rg3 and its metabolites in rat plasma using solid-phase extraction for pharmacokinetic studies [ J] . J Chromatogr B , 2005, 818(2) : 167-173.
[ 5] WANG N, WAN J B, LEE M Y , et al. Advances in stydies on <>Panax notoginseng against atherosclerosis [ J] . Chin Tradit Her Drugs( 中草药 ), 2008, 39(5) : 787-790.
[ 6] LU Z J, LIANG X G . Effect of <>Panax notoginsensides on apoptosis and apoptosis controling gene in vascular endothelial cell [ J] . Chin J Integr Med Cardio-Cerebrovas Dis ( 中西医结合心脑血管病杂志 ), 2005, 3(11) : 975-977.
[ 7] YAN Y F, ZHANG Z, SUN S L , et al. Protective effects of tatal saponin of <>Panax notoginseng and notoginsenosides on the hypoxia induced damage of cultured vascular endothelial cells in vitro [ J] . Chin J Exp Trandit Med Form( 中国实验方剂学杂志 ), 2002, 8(1) : 34-37.
[ 8] LI X Y, SUN J G, WANG G J ,<> et al. Protective effect study of major constituent in total Panax notoginsenoside on rat brain in microvessel endothelial cell(RBMEC) demage induced by H 2 O 2 [ J] . Chin Phramcol Bull( 中国药理学通报 ), 2007, 23(8) : 1030-1034 .
[ 9] IISHI H, TATSUTA M, BABA M,<> et al. Inhibition by ginsenoside Rg3 of bombesin-enhanced peritoneal metastasis of intestinal adenocarcinomas induced by azoxymethane in Wistar rats [ J] . Clin Exp Metastasis, 1997, 15(6) : 603-611.
[ 10] ZHANG Z M, JIANG B, ZHANG X X. Immune enhancing effects of Rg3 on peripheral lymphocytes in vitro in cancer patients treated with radiotherapy [ J] . Chin Pharm J( 中国药学杂志 ), 2004, 39(4) : 261-264.
[ 11] LOU X D, YANG Z C, LI A. Effects of endotoxin on culturing human umbilical vein endothelial cells [ J] . Chin J Tranmatol( 中华创伤杂志 ), 1998, 14(3) : 154-156.
[ 12] MARTINET W , DE MEYER G R. Autophagy in atherosclerosis [ J] . Curr Atheroscler Rep , 2008 , 10 ( 3 ) : 216-223 .
[ 13] ZHANG X, ZHANG C Y, WANG W, et al. Influence of the serum of radix ophiopogonis on the apoptosis related gene expression and intracellular Ca2+ in vascular endothelial cells treated with LPS [ J] . Chin J Pathophysiol( 中国病理生理杂志 ) , 2003, 19 (6) : 789-791.
[ 14] ZHANG X, XU D Q, ZHU P. Molecular mechanism of HUVEC apoptosis induced by LPS [ J] . Chin Arch Tradit Chin Med( 中医药学刊 ), 2006, 24 ( 12 ) : 2211-2213.
[ 15] WANG D X, WANG X M, XU J L. The protective effect of composite salviae dropping pills on human umbilical vein endothelial cells injured by lipopolysaccharide [ J] . Chin J Pathophysiol( 中国病理生理杂志 ) , 2006 , 22(5) : 933-937.
[ 16] SHEN Z Q, DONG Z J, CHEN P, <>et al. Modulation of PAI-1 and t-PA activity and thrombolytic effects of corilagin [ J]. Planta Med , 2003 , 69 (12) : 1109-1112.
[ 17] QIN L, ZHANG S Q, HUANG K R, et al. The study on relationship of atherosclerosis and fibrinolysis system and vascular endothelium function [ J]. J Apopl Nerv Dis( 中风与神经疾病杂志 ) , 2005 , 23 ( 2 ): 149-151.
[ 18] TANG X L, JIANG Z Y, WANG H D, et al. LPS Increases plasminogen activator inhibitor type-1 expression in human endothelia cells [ J] . Chin J Pathophysiol( 中国病理生理杂志 ) , 2006 , 22(4) : 687-691.
( 收稿日期 : 2008-12-05 )

PDF(2589 KB)

Accesses

Citation

Detail

Sections
Recommended

/