OBJECTIVE To synthesize antidepressant drug of escitalopram oxalate. METHODS Escitalopram oxalate was synthesized from 5-cyanophthalide by twice grignard reaction, hydrolysis, the optical resolution with(+)-DTTA, cyclization and then salification. RESULTS The structure of the product was determined by IR, MS and 1H NMR spectra. CONCLUSION This procedure was simple, reasonable and feasible.
Key words
escitalopram /
antidepressant drug /
synthesis
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References
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（ 收稿日期 ： 2008-10-12 ）
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