OBJECTIVE To investigate the chemical constituents of Excoecaria acerifclia F. Didr. and their antitumor activities. METHODS The constituents of EtOAc-soluble portion were isolated and purified by column chromatography. Their structures were identified by the their physicochemical properties and spectral features. The cytotoxicities of the purified compounds were evaluated by MTT method against human cancer cell lines HepG2. RESULTS Six compounds were isolated and identified as fraxin (1), isolariciresinol 9-O- β-D-glucopyranoside (2), (-)-5′-methoxyisolariciresinol 3a-O-β-D-glucopyranoside (3), gallic acid (4), isostrictiniin (5) and 3-O-feruloylquinic acid methyl ester (6). CONCLUSION All compounds were isolated from this plant for the first time. Compound 1 showed inhibitory activity towards HepG2 with IC50 values of 14.71 μmol·L-1.
Key words
Excoecaria acerifclia F. Didr. /
chemical constituents /
antitumor activities
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（ 收稿日期 ： 2008-12-10 ）
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