OBJECTIVE To prepare indapamide and organic acids complexes and to evaluate the transdermal absorption of the complexes. METHODS　Indapamide and organic acids complexes were prepared by ultrasound mixing method, and the solvent was natural evaporated. DSC method was used to determine the melting point of indapamide ant its complexes, and FT-IR method was used to identify the chemical structure. Using in vitro transdermal absorption experiments, the transdermal delivery properties of indapamide and its complexes were studied. RESULTS The spectrum of DSC and FT-IR indicated the formation of indapamide and organic acids complexes, and the result of in-vitro transdermal absorption experiments showed that accumulative amount of permeated indapamide was significantly (P<0.05) increased after the formation of indapamide and organic acids complexes．CONCLUSION Since indapamide has a low trandermal delivery amount, the preparation of indapamide and organic acids complexes may be a good method to promote the transdermal delivery of indapamide.