Abstract
OBJECTIVE To study the preparation of apigenin niosomes and their pharmacokinetics in rats and tissue distribution in mice.METHODS Apigenin niosomes was prepared by ethanol injection method.The pharmacokinetics and tissue distribution of apigenin niosomes and apigenin solution were carried out in Wistar rats and KM mice by caudal vein injection, respectively.RESULTS The entrapment efficiency of the niosomes was(69.48±2.5)% , the average particle size was(148±5.03)nm.Compared with apigenin injection,the circulation time of apigenin niosomes in plasma was longer.The t1/2 was increased by 2.02 fold ,the AUC0-∞ was increased by 1.85 fold and MRT0-∞ was increased by 2.16 fold.The AUCs0-∞ of liver,lung and brain were much bigger,while less in heart and kidney.CONCLUSION Apigenin niosomes can prolong the circulation in vivo,and reduce the accumulation in heart and kidney,which can improve curative effects and reduce toxicity.
Key words
apigenin /
niosomes /
pharmacokinetics /
tissue dirtubution /
nonionic surfactant
{{custom_keyword}} /
Cite this article
Download Citations
LIU Dn;HU Hi-yng;CHEN D-wei;LIU Ren;ZHO Xiu-li;QIO Ming-xi.
Pharmacokinetics and Tissue Distribution of Apigenin Niosomes [J]. Chinese Pharmaceutical Journal, 2009, 44(13): 1009-1013
{{custom_sec.title}}
{{custom_sec.title}}
{{custom_sec.content}}
References
[1] SUN B，QU W Q，ZHANG X L. The research progression in pharmacological action of apigenin [J]. J Chin Med Mater(中药材) ，2004，27(7):531-534.
[2] CHEN D I，DANIEL K D，CHEN M S，et al. Dietary flavonoids as proteasome inhibitors and apoptosis inducers in human leukemia cell[J]. Biochem Pharmacol，2005，69（10）：1421-1432.
[3] TAJDAR HUSAIN KHAN，SARWAT SULTANA. Apigenin induces apoptosis in Hep G2 cells:Possible role of TNF-α and IFN-γ[J]. Toxicol，2006，217（2-3）：206-212.
[4] ZHANG J A，ANYARAMBHATLA G，MA L，et al. Development and characterization of a novel Cremophorw EL free liposome-based paclitaxel (LEP-ETU) formulation[J]. Eur J Pharm Biopharm，2005，59（1）：177-187.
[5] SHI X G，ZHONG D F，ZHANG Y F，et al. Determination of silybin in the rat plasma by RP-HPLC [J]. J Shenyang Pharm Univ(沈阳药科大学学报)，2001，18(2)：113-115.
[6] GUPTA P K，HUNG C T. Quantitative evaluation of targeted drug delivery systems[J]. Int J Pharm，1989，56（2）：217-226.
[7] WANG S N，DENG Y H，XU H，et al. Synthesis of a novel galactosylated lipid and its application to the hepatocyte-selective targeting of liposomal doxorubicin[J]. Eur J Pharm Biopharm，2006，62（1）：32-38.
[8] ARUNOTHAYANUN P，BERNARD M S，CRAIG D Q M. The effect of processing variables on the physical characteristics of non-ionic surfactant vesicles (niosomes) formed from a hexadecyl diglycerol ether [J]. Int J Pharm，2000，201（1）：7-14.
[9] ARANYA MANOSROI，PAVEENA WONGTRAKUL，JIRADEJ MANOSROI，et al. Characterization of vesicles prepared with various non-ionic surfactants mixed with cholesterol [J]. Colloids Surf B Biointerfaces，2003，30（1-2）：129-138.
[10] XU C L，YAO H Y. Interaction between polyoxyethylene sorbitol fatty acid esters and liposome membrane [J]. Fine Chem(精细化工)，2004，21(12)：897-902.
[11] ZHOU W，WENG J Y，CHENG W Z，et al. Tissue distribution of paclitaxel fiposome in rats[J]. Chin Pharm J(中国药学杂志)，2005，40(18)：1402-1405.
[12] SONG X D，WANG X J，DU X，et al. Preparation of p-elemene liposomes and their tissue distribution in rats[J]. Chin J New Drugs Clin Rem(中国新药与临床杂志)，2007，26(10)：733-736.
[13] MARIA MANCONI，CHIARA SINICO，DONATELLA VALENTI， et al. Niosomes as carriers for tretinoin. I. Preparation and properties[J]. Int J Pharm，2002，234(1-2)：237-248.
[14] VYAS S P，SINGH R P，SANYOG JAIN，et al. Non-ionic surfactant based vesicles (niosomes) for non-invasive topical genetic immunization against hepatitis B[J]. Int J Pharm，2005,296(1-2)：80-86.
[15] YOSHIOKA T，STENBERG B，JLORENCE A T .Preparation and properties of vesicles (niosomes) of sorbitan monoesters (span20，40，60 and 80) and a sorbitan triester (span 85) [J]. Int J Pharm，1994，105（1）：1-6.
[16] ZHANG X B，XIE J Q，HOU X P. Effect of surfactants on the in vitro and in vivo properties of amphotericin B liposome [J]. Acta Pharm Sin(药学学报)，2003，38(6)：471-474.
[17] PAOLO BLASI，STEFANO GIOVAGNOLI，AURéLIE SCHOUBBEN. Solid lipid nanoparticles for targeted brain drug delivery[J]. Adv Drug Deliv Rev，2007，59(6)：454-477.
{{custom_fnGroup.title_en}}
Footnotes
{{custom_fn.content}}
