College of Pharmacy，Nanjing University of Chinese Medicine，Nanjing 210029，China
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History+
Received
Revised
Published
2008-06-25
2008-06-25
2008-06-25
Issue Date
2009-05-10
Abstract
OBJECTIVE To investigate pharmacokinetic properties of brucine in rats.METHODS The effect of administration route on pharmacokinetics of brucine was studied in rats.A single dose of 10 mg·kg-1 brucine solution was given by iv,ig or ip route.Plasma samples were drawn at intervals and the concentrations were determined by a validated HPLC method. Pharmacokinetic analysis was performed by 3P97 program.RESULTS The absolute bioavailabilities of ig and ip administration route were 33.3%and 74.9%.respectively.After ig or ip administration,pharmacokinetic characteristics were significantly changed, compared with iv route.The pharmacokinetic behavior after iv and ig administration was fitted with a two-compartment model, while ip administration was fitted with one-compartment model.CONCLUSION The administration route is the key factor which influences the pharmacokinetics of brucine in vivo.
CHEN Jun;HU Wei;CI o-chng;LOU Cheng-hu;WNG Li-jie;WNG Wei.
Pharmacokinetics of Brucine in Rats [J]. Chinese Pharmaceutical Journal, 2009, 44(10): 778-780
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