Pharmacokinetics of Curcumin Solid Dispersion in Rats in vivo

HN Gng;ZHI Li;ZHO Lin-lin;LIU Li;LIN Qing-hui;I Rui

Chinese Pharmaceutical Journal ›› 2009, Vol. 44 ›› Issue (09) : 698-700.

Chinese Pharmaceutical Journal ›› 2009, Vol. 44 ›› Issue (09) : 698-700.
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Pharmacokinetics of Curcumin Solid Dispersion in Rats in vivo

  • HAN Gang，ZHAI Li，ZHAO Lin-lin，LIU Li ，LIN Qing-hui， BI Rui
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Abstract

OBJECTIVE To prepare curcumin solid dispersion with Polyvinylpyrrolidone(PVP) and Polyethylene glycol(PEG),and to study the pharmacokinetics of curcumin solid dispersion in rats were used curcumin tablet as reference preparation.METHODS The rats were fed with curcumin solid dispersion and tablet.The curcumin concentration in whole blood was determined by HPLC.The date was processed by the 3P97.RESULTS The concentration-time curves of curcumin solid dispersion were diseribed with one-compartment model,The total areas under the plasma concentration-time curve AUC were larger than that of tablets and its bioavailability was 690%.CONCLUSION The curcumin solid dispersion could increase bioavailability in rats in vivo remarkably.

Key words

curcumin / solid dispersion / pharmacokinetics / polyvinylpyrrolidone / polyethylene glycol

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HN Gng;ZHI Li;ZHO Lin-lin;LIU Li;LIN Qing-hui;I Rui. Pharmacokinetics of Curcumin Solid Dispersion in Rats in vivo[J]. Chinese Pharmaceutical Journal, 2009, 44(09): 698-700

References

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