Study on Itraconazole Self-Emulsifying Drug Delivery System
CHEN Ying，ZHENG Qing-ling，LIU Hong，XIN Hua-wen
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Department of Pharmacy，Wuhan General Hospital of Guangzhou Command，Wuhan 430070，China
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History+
Received
Published
2007-11-19
2008-11-10
Issue Date
2008-11-10
Abstract
OBJECTIVE To develop the formulation of self-emulsifying drug delivery system for itraconazole(ITZ-SEDDS).METHODS The optimum formulations of ITZ-SEDDS were screened by solubility experiments,compatibility tests and pseudo-ternary phase diagrams,with the time of formulating emulsion,the consequence of visual examination and particle size as parameters.And the physic-chemical characters and dissolution in vitro of ITZ-SEDDS were also determined.RESULTS The optimum self-emulsifying drug delivery system was composed of Maisine 35-1(25%),Cremophor EL(30%) and Transcutol P(45%).The particle diameter was 162.5 nm,the time of self-microemulsifying was less than 1 min.The percent of accumulated dissolution of itraconazole in SEDDS in simulated intenstinal fluid was up to 90.9% at 2 h,which was 174.8 times as much as that of ITZ crude powder,and 9.0 times as much as that of ITZ capsules.CONCLUSION The formulation of ITZ-SEDDS prepared achieved the requirement of design.It could provide reference for the new dosage form of itraconazole.
CHEN Ying;ZHENG Qing-ling;LIU Hong;XIN Hu-wen.
Study on Itraconazole Self-Emulsifying Drug Delivery System [J]. Chinese Pharmaceutical Journal, 2008, 43(22): 1714-1718
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