Study on Sesquiterpene Components of Ligularia altaica DC.
ZHANG Chao-feng，WANG Qiong，ZHANG Mian
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Key Laboratory of Modern Chinese Medicines of Ministry of Education，Research Department of Pharmacognosy，China Pharmaceutical University，Nanjing 210038，China
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History+
Received
Published
2008-06-12
2008-11-10
Issue Date
2008-11-10
Abstract
OBJECTIVE To study the sesquiterpenes of the underground part of Ligularia altaica DC.and their cytotoxicity activity against K562 cell lines.METHODS Nine eremophilane sesquiterpenes were obtained as :furaneremophilan-14β,6α-olide(1),8β-hydroxyl-7(11)-eremophilen-12,8α-olide(2),7(11)-eremophilen-12,8α-olide(3),8β-hydroxyl-eremophil-7(11)-en-12,8α(14β,6α)-diolide(4),6β-hydroxyl-7(11)-eremophilen-12,8α-olide(5),6β,8β-dihydroxyl-7(11)-eremophilen-12,8α-olide(6),7-acetyl-6(7)-en-noreremophil-13β-carboxylic acid(7),8β-hydroeremophil-7(11)-en-12β,8α(14β,6α)-diolide(8) and 2-hydroxyl-plary phillide(9).CONCLUSION All compounds were obtained from this plant firstly,compound 7 and 9 showed relative weak inhibitory activities against K562 cell lines with IC50 as 65.27 and 54.71 mg·L-1,respectively.
ZHNG Cho-feng;WNG Qiong;ZHNG Min.
Study on Sesquiterpene Components of Ligularia altaica DC. [J]. Chinese Pharmaceutical Journal, 2008, 43(22): 1697-1699
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