Vasodilation Effect of Ferulaic Nitrate and Its Mechanism
WANG Zhan-qing1，CHEN Kai2，WANG Jin-ping1，JIANG Nan1， ZENG Ming1，XU Jing-feng1
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(1.General Hospital of Beijing Command of PLA，Beijing 100700，China；2.Institute of Pharmacology and Toxicology，Academy of Military Medical Sciences，Beijing 100850，China
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History+
Received
Published
2007-11-10
2008-11-05
Issue Date
2008-11-05
Abstract
OBJECTIVE To investigate the vasodilation effect and the possible mechanism of ferulaic nitrate(FLNT).METHODS The tensions of rat aorta artery and caval vein were measured.The comparison of vasorelaxation between FLNT and nitroglycerin(NG) or isosorbide dinitrate(ISDN) was made.And the blockers of guanylate cyclase(GC) and potassium channel were used to study the vasorelaxation mechanism of FLNT.RESULTS FLNT(1×10-7-1×10-4 mol·L-1) caused the concentration-dependent relaxation of rat caval vein and aorta artery.There is no significant difference between the endothelium-intact aorta rings and endothelium denuded aorta artery.In endothelium-intact aorta rings precontracted with norepinephrine(NE,1×10-6mol·L-1) or high level of K+(4×10-2 mol·L-1),FLNT relaxed almost the same degree as ISDN on aorta artery.FLNT caused unpaired shift of NE or KCl concentration-response curve to the right and decreased the maximum response.Without Ca2+,the contraction caused by NE was significantly inhibited by FLNT.The vessel tension of mythelene blue and some potassium channel blockers were reduced by FLNT on rat aorta rings.CONCLUSION FLNT induced concentration-dependent relaxation on rat aorta artery and caval vein.The relaxation of rat aorta was similar to isosorbide dinitrate and endothium-independent.The mechanism was possibly related to guanylate cyclase activation and potassium channel openening,and also possibly related to the inhibition of Ca2+ channel.
WNG Zhn-qing;CHEN Ki;WNG Jin-ping;JING Nn;ZENG Ming;XU Jing-feng.
Vasodilation Effect of Ferulaic Nitrate and Its Mechanism [J]. Chinese Pharmaceutical Journal, 2008, 43(21): 1624-1628
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