Abstract
OBJECTIVE To investigate the pharmacokinetics of tramadol hydrochloride in Chinese Han healthy volunteers.METHODS 10 Healthy volunteers were given with a single oral dose(100 mg) of Tramadol Hydrochloride Capsule.Blood samples were collected from vein at certain sampling times.Tramadol hydrochloride in plasma were determined by HPLC-fluorescence method,and the pharmacokinetic parameters were calculated by 3P97 software.RESULTS The plasma concentration-time curves of tramadol were fitted to a two-compartment model with a first order absorption.The main pharmacokinetic parameters were as follows: tmax(2.4±0.7) h,ρmax(401.4±77.9) μg·L-1,t1/2α(2.1±1.8)h,t1/2β(6.6±1.2)h,AUC0-36(4 249±1 290)μg·h·L-1,AUC0-∞(4 370±1 347)μg·h·L-1.CONCLUSION The pharmacokinetic parameters of tramadol in healthy volunteers after an oral single dose of tramadol hydrochloride capsule is concordant with that of the literature.There is no significant difference in the pharmacokinetic parameters between female and male subjects.
Key words
tramadol hydrochloride /
HPLC /
pharmacokinetics /
plasma concentration
{{custom_keyword}} /
Cite this article
Download Citations
XI Dong-y;WNG Yn-hui;GUO To.
Pharmacokinetics of Tramadol Hydrochloride in Chinese Han Healthy Volunteers [J]. Chinese Pharmaceutical Journal, 2008, 43(20): 1582-1584
{{custom_sec.title}}
{{custom_sec.title}}
{{custom_sec.content}}
References
[1] CHEN X Q，JIN Y Y，TANG G. New Pharmaceutics（新编药物学）[M] . 16th ed. Bejing: People’s Medical Publishing House，2007: 178-179.
[2] ZHU Y M. Effect and pharmacokinetics of tarmadol [J] . F Med Sci Anesth Resus（国外医学·麻醉学与复苏分册），2001，22（1）：56-58.
[3] WANG M，WEN A D，ZHAO L，et al. Pharmacokinetics and relative bioequivalence of tramadol hydrochloride in healthy volunters[J] . J Fourth Mil Med Univ（第四军医大学学报），2003，24（20）：1902-1904.
[4] LI H，WANG N，QIAO Z H，et al. Pharmacokinetics and relative bioavailability of tramadol hydrochloride tablet[J] . Clin J Clin Phamacol（中国临床药理学杂志），1995，11（1）：28-32.
[5] QARECIA-QUETGLAS E，AZANZA J R，SADABA B，et al. Pharmacokinetics of tramadol enantiomers and their respective phase Ⅰ metabolites in relation to CYP2D6 phenotype[J] . Pharmacol Res，2007，55(1):122-130.
[6] ROUINI M R， ARDAKANI Y H， SOLTANI F， et al. Development and validation of a rapid HPLC method for simultaneous determination of tramadol，and its two main metabolites in human plasma[J] . J Chromatogr B，2006，830(2): 207-211.
{{custom_fnGroup.title_en}}
Footnotes
{{custom_fn.content}}
