Determination of Human Plasma Protein Binding of EGCG by Ultrafiltration

WNG Li;REN Jun-gng

Chinese Pharmaceutical Journal ›› 2008, Vol. 43 ›› Issue (20) : 1579-1581.

Chinese Pharmaceutical Journal ›› 2008, Vol. 43 ›› Issue (20) : 1579-1581.
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Determination of Human Plasma Protein Binding of EGCG by Ultrafiltration

  • WANG Li,REN Jun-gang
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Abstract

OBJECTIVE To determine epigallocatechin gallate(EGCG) protein binding rate with human plasma protein.METHODS Ultrafiltration was employed to determine protein binding rate of EGCG with human plasma.RESULTS The average human plasma protein binding rates of EGCG from the study were 86.1%,91.4% and 94.9% with plasma concentration of 5.0,10.0 and 20.0 mg·L-1,respectively.CONCLUSION EGCG has higher protein binding extent with human plasma.

Key words

EGCG / plasma protein binding rate / ultrafiltration / HPLC

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WNG Li;REN Jun-gng. Determination of Human Plasma Protein Binding of EGCG by Ultrafiltration [J]. Chinese Pharmaceutical Journal, 2008, 43(20): 1579-1581

References

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