School of Pharmacy，Shenyang Pharmaceutical University，Shenyang 110016，China
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History+
Received
Published
2007-10-15
2008-10-10
Issue Date
2008-10-10
Abstract
OBJECTIVE To prepare bezafibrate Osmotic Pump Tablets and investigate the factors influencing the drug release.METHODS The Osmotic Pump Tablets were prepared with PEO as drug carriers and Na2CO3 as solubilizing agent.The factors that influenced drug release were examined by single factor investigation.RESULTS The water insoluble model drug of bezafibrate was prepared into Osmotic Pump Tablets.PEO had important effect on the early phase of drug release and Na2CO3 was conducive to the final release.CONCLUSION The preparation of osmotic pump of bezafibrate used small amount adjuvant,in addition,the drug release was stable during 12 h and had obvious characteristic of zero order release.
WU Heng;YNG Xing-gng;ZHNG Zhi-hong;LI Wei;PN Wei-sn.
Studies on Preparation of Osmotic Pump Tablets of Bezafibrate [J]. Chinese Pharmaceutical Journal, 2008, 43(20): 1574-1578
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References
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