Preparation of Trehalose Eye Drops Containing Sodium Hyaluronate
WAN Xiu-yu1，LING Pei-xue2*，ZHU Qi-deng1，ZHANG Tian-min2
Author information+
1. Shandong Bausch & Lomb Freda Pharmaceutical Co.，Ltd.，Jinan 250014，China；2. School of Pharmacy ，Shandong University，Jinan 250012，China
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History+
Received
Published
2007-08-11
2008-06-05
Issue Date
2008-06-05
Abstract
OBJECTIVE To study and develop trehalose eye drops containing SH for the treatment of ophthalmoxerosis.METHODS The formulation of the eye drops was selected.By optimization of samples pretreatment conditions,the method for determining the content of trehalose in the eye drops was established.The effects on the ophthalmoxerosis in the model of mice were evaluated.RESULTS The conditions of samples pretreatment for assay were as follows:2.0% sodium chloride,2.5-4.0 ratio of the volume of anhydrous alcohol to the sample,standing for 30 min,filtrated by 20 μm film.The mean recovery was 100.6%with RSD of 0.61%.Fluorescein staining scores,tear secretion,and goblet cells density were improved significantly as well as corneal and conjunctiva epithelial morphology were recovered with trehalose eye drops compared with 0.1% SH.CONCLUSION Trehalose eye drops containing SH with reasonable formulation is effective for the treatment of ophthalmoxerosis.
WN Xiu-yu;LING Pei-xue;ZHU Qi-deng;ZHNG Tin-min.
Preparation of Trehalose Eye Drops Containing Sodium Hyaluronate [J]. Chinese Pharmaceutical Journal, 2008, 43(11): 838-840
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