Abstract
OBJECTIVE To investigate the absorption characteristics and mechanism of the total flavones of epimedium for various intestinal segments.METHODS The intestine in rats was cannulated for in situ recirculation.RESULTS Icariin was metabolized quickly in the four intestinal segments.The permeability coefficients(Peff) were(5.25±0.17),(4.27±0.28),(1.99±0.09) and(0.80±0.03) at duodenum,jejunum,ileum and colon,respectively,and the permeability coefficients(Peff) of Icariin in the total flavones of epimedium were(3.65±0.18),(4.68±0.17),(1.64±0.08) and(0.58±0.26) at duodenum,jejunum,ileum and colon,respectively.CONCLUSION Some compositions of the total flavones of epimedium show metabolic transformation,and Icariin shows obviously metabolism.
Key words
icariin /
total flavones of epimedium /
absorption-kinetic /
in situ perfused rat intestinal model
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ZHO Yn-hong;JI Xio-in;CHEN Yn;FN Chen-yi;MING Hu.
Studies on Rat Intestinal Absorption of the Total Flavones of Epimedium in Situ [J]. Chinese Pharmaceutical Journal, 2008, 43(03): 188-191
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