Studies on Preparation of rhG-CSF Liposomes and Its Release Behavior in Vitro
MA Jing，DENG Shu-hai
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Pharmaceutical Institute of Shandong University，Jinan 250012，China
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History+
Received
Published
2007-01-22
2008-01-10
Issue Date
2008-01-10
Abstract
OBJECTIVE To study the preparation of rhG-CSF liposomes and its properties in vitro.METHODS The liposomes were prepared by pro-liposomes technique.The Zeta potential,particle size distribution,the entrapment efficiency and the release behavior of rhG-CSF liposomes in vitro were studied.RESULTS The mean diameters of rhG-CSF liposomes were(195.2±40.8) nm.The Zeta potential was-(45.5±2.97)mV.The mean entrapment efficiency was(84.2±0.36)%.The release of rhG-CSF in rhG-CSF liposomes were significantly delayed.CONCLUSION The rhG-CSF liposomes were prepared by pro-liposomes technique,with high entrapment efficiency and prolonged biological half life.
M Jing;DENG Shu-hi.
Studies on Preparation of rhG-CSF Liposomes and Its Release Behavior in Vitro[J]. Chinese Pharmaceutical Journal, 2008, 43(02): 124-126
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