Study on Preventive and Therapeutic Effects of Sulfated Pachyman Salt of L-Ornithine on Renal Failure Induced by Adenine in Rats
YANG Zhong-hao，CHEN Qun，JIAO Qing-cai
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College of Life Science，State Key Laboratory of Pharmaceutical Biotechnology，Nanjing University，Nanjing 210093，China
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Received
Published
2006-12-01
2008-01-05
Issue Date
2008-01-05
Abstract
OBJECTIVE To investigate the preventive and therapeutic effects of sulfated pachyman(SP) and its salt of L-ornithine(SP-Orn) on renal failure induced by adenine in rats.METHODS The rats were administrated with adenine to induce renal failure at a dose of 250 mg·kg-1·d-1 for 21 d.From the fifth day on,SP and SP-Orn were given to two groups treated with the doses of 450 and 700 mg·kg-1·d-1 respectively.After 30 d treatment,the urine excreted within 12 h was collected.The volume of urine,the contents of urinary creatinine(Ucr) and urinary protein were determined.Blood was drawn from the ophthalmic venous plexus and the contents of serum creatinine(Scr),blood urea nitrogen(BUN),total protein(TP) and albumin(ALB) were determined.The morphological changes of kidneys were observed.RESULTS Compared with those of model group,after 30 d treatment,SP and SP-Orn significantly increased the volume of urine,the contents of Ucr,as well as serum TP and ALB,and declined the contents of urinary protein,Scr and BUN.The levels of serum TP and urinary protein were nearly equivalent to those of normal control group.And also,SP and SP-Orn alleviated the injuries of the kidneys.As a whole,the therapeutic effect of SP-Orn was better than that of SP.CONCLUSION SP and SP-Orn appeared to have a promising therapeutic effects on renal failure.There was a synergetic effect between SP and SP-Orn on curing renal failure in rats.
YNG Zhong-ho;CHEN Qun;JIO Qing-ci.
Study on Preventive and Therapeutic Effects of Sulfated Pachyman Salt of L-Ornithine on Renal Failure Induced by Adenine in Rats [J]. Chinese Pharmaceutical Journal, 2008, 43(01): 31-34
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