Abstract
OBJECTIVE To study the effects of the spent culture supernatant(SCS) of Lactobacillus acidophilus strain LA14 on experimental diarrhea in mice.METHODS 100 Mice were randomly divided into 10 groups.The animal model of the experimental diarrhea was made by intraperitoneal administration of 80 g·L-1 decoction of Cassia angustifolia leaf(25 mL·kg-1) or castor oil(15 mL·kg-1) to mice.Before the model was made,SCS,living bacteria,SCS plus living bacteria(25 mL·kg-1 times) and Smecta(3 g·kg-1 times) were respectively administered(twice per day)to mice for three days.After the model was made,the accumulated times of diarrhea,the ratio of diarrhea and the ratio of loosing stool of mice were measured within six hours.RESULTS In SCS group,living bacteria group and SCS plus living bacteria group,the ratios of loosing stool in mice with two kinds of experimental diarrhea were reduced.Compared with model group,the difference was significant(P<0.05 or P<0.01).Meanwhile the accumulated times of diarrhea in mice of different time points were also decreased in varying degrees.Compared with model group,the difference was statistically significant(P<0.05 or P<0.01).CONCLUSION Both SCS of Lactobacillus acidophilus and living bacteria have certain anti-diarrhea actions to the experimental diarrhea of mice.
Key words
Lactobacillus acidophilus /
spent culture supernatant (SCS) /
diarrhea
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LUO Xue-y;GO Wei;JI Cong-wei;QI ing-di;WNG Ji-ren;LI Jin-hong.
Effects of Spent Culture Supernatant of Lactobacillus Acidophilus on Experimental Diarrhea [J]. Chinese Pharmaceutical Journal, 2007, 42(24): 1908-1910
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