Studies on Synthesis of Rutin-Se Complex and Their Antitumor Activities

ZHOU Peng;WU Jin-zhng;QIU Pei-hong;GUO Ping;XIO Jin;YE F-qing

Chinese Pharmaceutical Journal ›› 2007, Vol. 42 ›› Issue (24) : 1905-1907.

Chinese Pharmaceutical Journal ›› 2007, Vol. 42 ›› Issue (24) : 1905-1907.
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Studies on Synthesis of Rutin-Se Complex and Their Antitumor Activities

  • ZHOU Peng,WU Jian-zhang,QIU Pei-hong*,GUO Ping,XIAO Jian,YE Fa-qing
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Abstract

OBJECTIVE To study the design and synthesis of rutin-Se complex and its antitumor activities.METHODS Rutin-Se complex was designed and synthesized from rutin and SeOCl2,and their antitumor activities were tested against CNE2,HEP2,BEL-7404,KB and HELA cells by MTT method compared with rutin.RESULTS The structures of complex were determined by UV,IR,LC-MS and 1H-NMR.The preliminary pharmacological tests showed that rutin-Se displayed significant growth inhibition on CNE2,HEP2,BEL-7404,KB and HELA cells.Their IC50 were 26.78,0.42,8.37,1.89 and 0.35 mg·L-1 respectively,but rutin promoted CNE2,HEP2 and BEL-7404 cells generation.CONCLUSION Rutin-Se complex can be regarded as effective potential antitumor agents and it is worthy of being investigated continually.

Key words

synthesis / rutin / rutin-Se complex / antitumor activities

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ZHOU Peng;WU Jin-zhng;QIU Pei-hong;GUO Ping;XIO Jin;YE F-qing. Studies on Synthesis of Rutin-Se Complex and Their Antitumor Activities [J]. Chinese Pharmaceutical Journal, 2007, 42(24): 1905-1907

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