Study on Pharmacokinetics of Guaifenesin Sustained Release Pellets in Beagle Dogs
XIONG Long-qi，CHEN Qing-hua
Author information+
Shanghai Institute of Pharmaceutical Industry，Shanghai 200437，China
{{custom_zuoZheDiZhi}}
{{custom_authorNodes}}
{{custom_bio.content}}
{{custom_bio.content}}
{{custom_authorNodes}}
Collapse
History+
Received
Published
2006-07-19
2007-10-10
Issue Date
2007-10-10
Abstract
OBJECTIVE To study the pharmacokinetics of guaifenesin sustained release pellets in healthy beagle dogs and to evaluate the bioequivalence.METHODS The concentrations of guaifenesin in plasma were determined by RP-HPLC.The pharmacokinetic parameters were calculated and the relative bioequivalence was evaluated.RESULTS The main pharmacokinetic parameters of guaifenesin sustained release pellets were as follows:AUC0-16(20 407.49±2 120.62)μg·h·L-1;tmax(0.92±0.36)h;ρmax(3 699.85±806.39)mg·L-1;Ke(0.20±0.039)h-1;t1/2(Ke)(3.58±0.64)h,respectively.The relative bioavailability of AUC0-16 and AUC0-inf were(99.8±9.8)% and(101.6±10.1)%.CONSLUSION The reference and test formulations are bioequivalent.
XIONG Long-qi;CHEN Qing-hu.
Study on Pharmacokinetics of Guaifenesin Sustained Release Pellets in Beagle Dogs [J]. Chinese Pharmaceutical Journal, 2007, 42(20): 1574-1576
{{custom_sec.title}}
{{custom_sec.title}}
{{custom_sec.content}}
References
[1] ZHAO L H，HUANG J，LIU Y H. Determination of guaifenesin and dextromethorphan hydrobromide in sustained-release tablets by HPLC[J] . Chin J Mod Apol Pharm(中国现代应用药学杂志)，2002，16(6)：491-492.
[2] WAGNER D L，PATEL V S. Steady-state human pharmacokinetics and bioavailability of guaifene-sin and pseudoephedrine in a sustained-release tablet relative to immediate-release liquids[J] . Int J Pharm，1995，114：171-176.
[3] LIU H，ZHI D G，GAO J，et al.Study on the pharmacokinetics of compound Yumameifen sustained-release tablets in Beagle dogs [J] . J Shenyang Pharm Univ(沈阳药科大学学报)，2004，21(5)：328-345.
[4] DU Y，ZHONG D F，ZHAO L，et al. Studies on pharmacokinetics of Yu-mei dissoluble Tablets and bioequivalence of its two formulation[J] . J Shenyang Pharm Univ(沈阳药科大学学报)，2001，18(3)：157-161.
