OBJECTIVE To establish a method for the determination of the four contents of paracetamol,pseudoephedrine hydrochloride,dextromethorphan hydrobromide,and chlorphenamine maleate in oral disintegrating tablets by HPLC.METHODS The samples were separated on a LiChroCART column(4.6 mm×150 mm,5 μm) was used.The mobile phase consisted of methanol0.75% acetic acid(25∶75) and the ultraviolet wavelength was at 280 nm for paracetamol.On the other hand,the separation was performed on a Luna SCX 100A column(4.6 mm×250 mm,5 μm) with a mobile phase of acetonitrile-0.05 mol·L^-1 potassium dihydrogen phosphate(68∶32) for the determination of dextromethorphan hydrobromide,pseudoephedrine hydrochloride and chlorphenamine maleate, the detect wavelength was 265 nm.RESULTS The calibration curves were linear in the range of 10.0～100.0 mg·L^-1 for paracetamol(r=1.000 0),5.161～25.80 mg·L^-1 for dextromethorphan hydrobromide(r=1.000 0),0.978～4.890 mg·L^-1 for chlorphenamine maleate(r=0.998 8),14.93～74.64 mg·L^-1 for pseudoephedrine hydrochloride(r=1.000 0).The average recoveries were 99.7% with RSD of 1.53%;100.4% with RSD of 1.09%;99.2% with RSD of 1.93%;97.6% with RSD of 1.21% for four above mentioned components,respectively.CONCLUSION The method is accurate and reliable for the quality control of this compound preparation.