One-Step Synthesis of 3-oxo-Δ4,6 Steroids

DENG Xi-fei;FENG Chng-gen;ZHNG Tong-in;YNG Yn-qing

Chinese Pharmaceutical Journal ›› 2007, Vol. 42 ›› Issue (07) : 548-549.

Chinese Pharmaceutical Journal ›› 2007, Vol. 42 ›› Issue (07) : 548-549.
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One-Step Synthesis of 3-oxo-Δ4,6 Steroids

  • DENG Xia-fei1，FENG Chang-gen1，ZHANG Tong-bin2，YANG Yan-qing2
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Abstract

OBJECTIVE To study the synthetic process for 3-oxo-Δ4,6 steroids using 3-hydroxy-Δ5 steroids as starting materials.METHODS Using the bromine, the lithium bromide and the promoter pyridine carried out the oxidized dehydrogenation.RESULTS The target compound was obtained and purified yield was over 60%.CONCLUSION The process provides high yields with inexpensive cost and has one-step synthesis.

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3-hydroxy-Δ5 steroids / 3-oxo-Δ4 / 6 steroids / one-step synthesis

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DENG Xi-fei;FENG Chng-gen;ZHNG Tong-in;YNG Yn-qing. One-Step Synthesis of 3-oxo-Δ4,6 Steroids [J]. Chinese Pharmaceutical Journal, 2007, 42(07): 548-549

References

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