1. Huazhong Agriculture University， a.College of Science；b.College of Animal Husbandry and Veterinary Medicine ，Wuhan 430070，China；2.Zhang Zhong-Jing College of Traditional Chinese Medicine，Nanyang 473061，China
{{custom_zuoZheDiZhi}}
{{custom_authorNodes}}
{{custom_bio.content}}
{{custom_bio.content}}
{{custom_authorNodes}}
Collapse
History+
Received
Published
2005-12-13
2007-03-10
Issue Date
2007-03-10
Abstract
OBJECTIVE To prepare praziquantel solution at high concentration and to investigate its transdermal delivery and worm-reduction effect on Schistosomiasis japoricum in mice.METHODS The stability of the solution was evaluatad by experiments.The solubility of praziquantel solution at different temperature was measured by UV spectrophotometer.The praziquantel concentrations in rabbit plasma were determined by HPLC.The praziquantel solution of 70,150,200 g·L-1,were applied to the experimental therapy of Schistosomiasis japonicum in mice.RESULTS The praziquantel solution at high concentration showed good stability.From 35 to 45 ℃, there was a great change in the solubility of praziquantel in the solvent(284 g·L-1→456 g·L-1).The absorption rate of transdermal delivery was faster than that of oral administration.The AUC and ρmax of the former was as 2.1 times and 4.0 times as oral administration.The praziquantel solution reached prefect therapy efficacy with the worm-reduction of 100%. CONCLUSION The solution containing high praziquantel concentration may be a promising vehicle for the transdermal delivery of praziquantel.
ZHENG Xin-sheng;ZHENG Xin-n;HUNG Jing;DUN Cun-zheng;YO o-n.
Study on Transdermal Absorption of Praziquantel Solution at High Concentration and Its Worm-Reduction Effect on Schistosomiasis Japonicum in Mice [J]. Chinese Pharmaceutical Journal, 2007, 42(06): 450-453
{{custom_sec.title}}
{{custom_sec.title}}
{{custom_sec.content}}
References
[1] YU Y，YAN S H，HU X L，et al.Preparation of liposome of levo-praziquantel and praziqantel and their comparative efficacy in experimental therapy of in mice [J] .West China Pharm J(华西药学杂志)，1999，14（5）：215-318.
[2] YU Y，YAN S H. Advance in research of praziqantel in therapy of Schitosomiasis [J] .Chongqing Med Univ J（重庆医科大学学报），1990，15(1)： 82-87.
[3] BEVERLEY J T，BARRIE C F. The transdermal revolution[J] . Res Focus，2004，9(16)：697-702.
[4] GREGORIOS G A，PARASKEVAS P D，DIMITRIOS M R. Development and in vitro evaluation of furosemide transdermal formulations using experimental design techniques[J] .Int J Pharm，2004，281：35-41.
[5] WANG Z H，PENG H L， LU M，et al. Study of praziquantel -TTS on animals infected with Schitosoma japonicum[J] .Chin J Schistosomiasis Control(中国血吸虫病防治杂志)，1994，6（6）：331-334.
[6] YANG W Z，ZHENG J M，HAO J S. Preparation of praziquantel hydrogel[J] .Chin J Pharms(中国医药工业杂志)，1998，29(4)：161-163.
[7] QI X H，CHRISITA A.Physicochemical characterization and percutaneous delivery of 2，3，5，6-tetramethylpyrazine[J] . Int J Pharm，2003，253：177-183.
[8] BAO J L，YANG Y Y，WANG H，et al.Network thermodynamics model of conductance for drug transport through skin[J] .Acta Biophysica Sin (生物物理学报)，2004，20（5）：413-418.
[9] JIN Y M，HUANG M X，LIU Z Q.The effective comparison of different drugs and administrational routes to prevent infection with Schistosoma japonicum in mice [J] .Chin J Parasit Dis Con(中国寄生虫病防治杂志)，2002，15（15）：308-310.
