Protective Effect of Ginseng Fruit Saponins on Experimental Myocardial Infarction in Dogs
WU Yi，YU Xiao-feng，QU Shao-chun，SUI Da-yuan
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Department of Pharmacology，School of Pharmacy， Jilin University，Changchun 130021，China
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History+
Received
Published
2005-12-10
2007-03-05
Issue Date
2007-03-05
Abstract
OBJECTIVE To study the protective effect of Ginseng fruit saponins(GFS) on experimental myocardial infarction in dogs.METHODS The acute myocardial infarct model was induced by left anterior descending coronary occulusion for 6 h in dogs.After 90 min treatment by GFS,the changes of myocardial ischemic extent(△Σ-ST),myocardial ischemic area(△N-ST),myocardial infarct size(MIS),the activities of creatine phosphokinase(CPK),aspartate aminotransferase(AST),lactate dehydrogenase(LDH),superoxide dismutase(SOD) and glutathione peroxidase(GSH-Px),the contents of lipid peroxidation(LPO) and free fatty acid(FFA) in serum were determined.RESULTS After being treated by GFS(2.5～10 mg·kg-1,infusion for 90 min),△Σ-ST,△N-ST and MIS were significantly reduced,the activities of CPK,AST,LDH and the contents of LPO and FFA in serum were declined, while the activities of SOD,GSH-Px in serum were increased markedly.CONCLUSION The results suggest that GFS have protective effect on experimental myocardial infarction in dogs,which may be related to improving myocardial metabolism,increasing the activity of antioxidiase,and eliminating the free radicals etc.
WU Yi;YU Xio-feng;QU Sho-chun;SUI D-yun.
Protective Effect of Ginseng Fruit Saponins on Experimental Myocardial Infarction in Dogs [J]. Chinese Pharmaceutical Journal, 2007, 42(05): 345-348
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References
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