OBJECTIVE To investigate the pharmacokinetics of Faropenem sodium in Chinese healthy volunteers. METHODS 30 Healthy volunteers (15 male, 15 female) were divided into three groups randomly,and were given a single oral dose (200, 400, 600 mg) of Faropenem sodium tablet.Blood samples were collected from elbow vein at certain sampling times. Faropenem in plasma was determined by HPLC method, and the pharmacokinetic parameters were calculated by DAS software.RESULTS The plasma concentration-time curves of Faropenem are fitted to an one-compartment model after an oral Faropenem sodium tablet in single dose(200, 400, 600 mg). The main pharmacokinetic parameters were as follows:t_max(0.85±0.29),(0.73±0.34) and (0.88±0.29)h;ρ_max (2.154±0.65),(4.425±2.403) and (8.126±2.635)mg·L^-1;AUC_0-t(4.368±1.934),(9.273±7.817) and (18.431±9.167) mg·h·L^-1;t_1/2(0.642±0.111),(0.769±0.217) and (0.702±0.120) h, respectively.CONCLUSION The plasma concentration-time curves of Faropenem are fitted to an one-compartment model in 30 healthy volunteers after an oral Faropenem sodium tablet in single dose (200, 400, 600 mg), and the ρ_max, AUC are increased with dose rising. There is no significant difference in the pharmacokinetic parameters between female and male.