a.Department of Pharmaceutics,School of Pharmacy;b.School of Life Science,Fudan University,Shanghai 200032,China
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History+
Received
Published
2005-12-22
2006-12-05
Issue Date
2006-12-05
Abstract
OBJECTIVE To prepare pectin-calcium chloride matrix tablets and evaluate indomethacin release profiles in vitro.METHODS Wet granulation technique was employed to prepare pectin-calcium chloride matrix tablets. The amount of calcium chloride, the mass ratio of calcium chloride-pectin and release media on drug release profiles were investigated. Matrix erosion and water uptake were performed to elucidate the mechanisms of calcium chloride on drug release. RESULTS The ratio of pectin-calcium chloride and mass ratio of drug-matrix were important factors on the drug release. The pectin-calcium chloride matrix tablets had different release profile in various media. The drug release rate was positively correlated to matrix erosion rate and the relative water uptake rate. The drug released quickly and completely with the Pectinex Ultra SP-L.CONCLUSION The pectin-calcium chloride-based matrix tablets can form relative rigid gel by cross-linking between pectin and calcium ions in situ. This kind of system has potential to be used to target drugs to the colon.
WEI Xiu-li;SUN Ning-yun;WU o-jin;WU Wei;XU Hui-nn.
Effect of Calcium Choloride on Indomethacin Release from Pectin-Based Matrix Tablets [J]. Chinese Pharmaceutical Journal, 2006, 41(23): 1804-1808
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