Department of Basic Medical Sciences，Lanzhou University，Lanzhou 730000，China
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History+
Received
Published
2005-06-01
2006-11-05
Issue Date
2006-11-05
Abstract
OBJECTIVE To study the effects of rhubarb(dried root of Rheum officinale Baill.)on the contractile activity of isolated antral circular strips of guinea pigs and its possible mechanism. METHODS Antral circular strips from guinea pigs were suspended in organ baths containing Krebs solution, and then isometric tension was measured. The response to rhubarb at different concentrations(1%, 3%,10%, 30% and 100%)and the effect of atropine(10-6 mol·L-1), verapamil(5×10-8 mol·L-1)and hexamethonium(10-5 mol·L-1)on rhubarb-induced contraction were assessed.RESULTS The rhubarb dose dependently increased the mean contractile amplitude and the resting tension of circular muscle of gastric antrum. 100% rhubarb increased the contractile frequency of circular muscle of gastric antrum. Atropine, verapamil and hexamethonium partly blocked the increased action of rhubarb on the isolated strips of gastric antrum in guinea pigs. CONCLUSION Rhubarb has exciting actions on isolated antral circular strips of guinea pig, which is partly mediated via cholinergic M receptor, cholinergic N receptor and L-type calcium channel.
YU Mei;LUO Y-li;ZENG Jun-wei;ZHNG Xio-yu;LI Wei;ZHENG Tin-zhen;QU Song-yi.
Effects of Rhubarb officinale on Antral Circular Strips of Guinea Pigs [J]. Chinese Pharmaceutical Journal, 2006, 41(21): 1632-1634
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