HE Yan-li1，2，LOU Hong-xiang1，WANG Yu-ling2，CHEN Jian-ying2
Author information+
1.School of Pharmacy，Shandong University，Jinan 200012，China; 2. Shandong Institute of Biopharmaceuticals，Jinan 250014，China
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History+
Received
Published
2005-05-20
2006-09-05
Issue Date
2006-09-05
Abstract
OBJECTIVE To investigate the synthesis of bis-(sulfosuccinimidyl)suberate(BS3),3,3′-dithiobis(sulfosuccinimidyl)propionate(DTSSP), 4,4′-dithiobis(sulfosuccinimidyl)butylate(DTSSB), and find a convenient, small-toxicity and low-cost process.METHODS Sulfo-N-hydroxy succinimide sodium was prepared from maleic anhydride, via four steps, including addition, cyclization, reduction and cyclizative condensation. The target compound was obtained by sulfo-N-hydroxy succinimide sodium reacting with corresponding dicarboxylic acid.RESULTS The target compound was provided through a five-step procedure starting from maleic anhydride with corresponding total yields of 31%,24%and 35% respectively. The structure was verified by 1H-NMR and HRMS.CONCLUSION The synthetic route is cost-efficient, facile and suitable for the large-scale preparation of the target compounds.
HE Yn-li;LOU Hong-xing;WNG Yu-ling;CHEN Jin-ying.
Synthesis of Hyaluronic Acid Cross-Linkers [J]. Chinese Pharmaceutical Journal, 2006, 41(17): 1350-1352
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References
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