OBJECTIVE To investigate the effect of N-acetylcysteine on the metabolism of alcohol and the antagonism to the damage of liver caused by alcohol.METHODS The mice were divided into several groups randomly,and were orally given distilled water and different doses of NAC respectively.After 20 min,the mice were orally given alcohol.Then their righting reflex and climb capacity were observed;the activities of ADH,SOD,GST,GSH-Px and the contents of GSH and MDA in liver were measured by chromatometry and colorimetric method.The alcohol concentration in blood was measured by GC.RESULTS NAC significantly reduced the drunk rate of mice after being given alcohol,prolonged their tolerance time,and restrained the decreasing of mice climb capacity induced by alcohol.NAC reduced the blood concentration of alcohol in drunken mice,and increased the activity of ADH,which accelerated the metabolism of the alcohol.NAC increased the activity of SOD,GST,GSH-Px and the content of GSH,which was benefit for eliminating the free radical.NAC reduced the content of the MDA in liver.And all of the above effects of NAC were dose dependent.CONCLUSION NAC has the effect of promoting the metabolism of alcohol and antagonizing the damage of liver caused by alcohol.
LIU Xi;LI Chng-ling;YIN Gung-yu;QUN Long-ho.
Effects of N-Acetylcysteine on Metabolism of Alcohol and Its Mechanism Research [J]. Chinese Pharmaceutical Journal, 2006, 41(14): 1063-1065
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