Study on Isolation and Neurotrophic Activity of Polysaccharides from Rosa roxburghii

YNG Jun;YNG Fu-mei;SUN Qin-yun

Chinese Pharmaceutical Journal ›› 2006, Vol. 41 ›› Issue (13) : 980-982.

Chinese Pharmaceutical Journal ›› 2006, Vol. 41 ›› Issue (13) : 980-982.
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Study on Isolation and Neurotrophic Activity of Polysaccharides from Rosa roxburghii

  • YANG Juan，YANG Fu-mei，SUN Qian-yun
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Abstract

OBJECTIVE To study the isolation and neurotrophic activity of polysaccharides from Rosa roxburghii Tratt.METHODS RRTP-1～RRTP-8 were isolated by DEAE-cellulose and Sepharose CL-6B column chromatography from crude polysaccharide.Their homogeneity was determined by gel column chromatography and electrophoresis.Neurotrophic activity of RRTP-1～RRTP-8 was screened by PC12 cell assay.Quantitative neurotrophic assays to homogeneous polysaccharides were carried out.RESULTS RRTP-1 and RRTP-3 were homogeneous polysaccharides.The screening results showed that most of polysaccharide fractions induced the differentiation of PC12 cell.CONCLUSION The most of polysaccharide fractions from Rosa roxburghii Tratt have obvious neurotrophic activity.

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Rosa roxburghii Tratt / polysaccharide / isolation / neurotrophic activity

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YNG Jun;YNG Fu-mei;SUN Qin-yun. Study on Isolation and Neurotrophic Activity of Polysaccharides from Rosa roxburghii[J]. Chinese Pharmaceutical Journal, 2006, 41(13): 980-982

References

[1] WANG W，XIA B N. Advances of Rosa roxburghii Tratt[J] .Chin Pharm J (中国药学杂志)，1996，31 (11)： 643-645. [2] FANG J N，DING K. Preparation and application of floral polysacchride and its derivatives from Nerium indicum mill [P] . Chin Pat(中国专利). (CN99125746.4)，24 Dec 1999，China. [3] YANG J，WU M C，ZHANG S H. Study on isolation，purification and characteristics of polysaccharide Le-Ⅲ from the fruitbody of Lentinus edodes[J] .J Huazhong Agri Univ (华中农业大学学报)，1999，18 (2)：188-190. [4] BITTER T，MUIR H M. A modified uronic acid carbazole reaction[J] . Anal Biochem，1962，4： 330-334.

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