Abstract
OBJECTIVE To investigate the nasal absorption of ginsenoside Rg1 and the absorption enhancen effect of borneol.METHODS The effect of ginsenoside Rg1 and borneol on cililary movement were evaluated by in situ toad palate model.Nasal circulatory perfusion test in vivo was employed to investigate the characteristics of nasal mucosa absorption ginsenoside Rg1 in rats.The electron microscope scanning technique was used to evaluate the nasal ciliotoxicity of ginsenoside Rg1 and borneol on the nasal mucosas of the rats.RESULTS When the concentrations of ginsenoside Rg1 were 100,250,500 mg·L-1,respectively,the corresponding values of the absorption rate were 0.000 30,0.000 40 and 0.000 7 min-1.However,when the concentration of ginsenoside Rg1 was 250 mg·L-1in circulation liquid,the absorption rates were 0.001 9,0.001 2 and 0.001 3 min-1 with the aid of borneol of 10,20 and 30 g·L-1.CONCLUSION Ginsenoside Rg1 can be absorbed through the nasal mucous and borneol can enhance the absorption.The Ginsenoside Rg1 spray has no damage to the nasal mucosas of rats.
Key words
ginsenoside Rg1 /
borneol /
nasal absorption /
nasal ciliotoxicity
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CHEN Xin-mei;ZHU Ji-i;SUN Wei-dong;ZHNG Li-jin.
Effect of Absorption Enhancer of Borneol on Ginsenoside Rg1 and the Nasal Ciliotoxicity [J]. Chinese Pharmaceutical Journal, 2006, 41(04): 261-264
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