Study on treatment of AD by NGF liposomes via nasal administration
XIE Ying,DU Yi,GENG Xing-chao,HOU Xin-pu
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Department of Pharmacy, School of Pharmaceutical Sciences, Peking University, Beijing 100083,China
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History+
Received
Published
2004-06-04
2005-05-10
Issue Date
2005-05-10
Abstract
OBJECTIVE To study the pharmacodynamic parameters of NGF and NGF sterically stabilized liposomes(NGF-SSL) via nasal administration and compare with NGF intravenous inject. METHODS Alzheimer's disease (AD) model was made by Meynert nucleus injected with ibotenic acid(IBO), and was evaluated by the water maze, footshock avoidance and AchE Histochemistry staining tests. The pharmacodynamic parameters of NGF (iv) and NGF, NGF-SSL (na) were studied by using the AD model. RESULTS AD model was appraised to be suitable for studying the pharmacology efficacy of NGF. The pharmacodynamics of NGF via nasal administration was better than that of NGF intravenous inject, and that of NGF-SSL via nasal administration was further improved. Nasal administration protected the cholinergic neuron from being damaged by IBO, the swim time of the rats was shorten, and the footshock avoidance latency was extended, the integral spectro-density of AchE staining was near to that of control rats.CONCLUSION Nasal administration is a better way to target the brain, and the brain uptake of drug modified with lioposomes would be increased, the pharmacodynamics would be improved.
XIE Ying;DU Yi;GENG Xing-cho;HOU Xin-pu.
Study on treatment of AD by NGF liposomes via nasal administration [J]. Chinese Pharmaceutical Journal, 2005, 40(10): 742-745
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