OBJECTIVE To investigate the losses of fifteen injectable drugs from aqueous solutions (0.9% sodium chloride and 5% dextrose) stored in M312 Non-PVC infusion bags (NPVC), glass bottles (G) and PVC infusion bags (PVC) respectively for 48 hours and compare their sorption characteristics METHODS Each drug was separately added to above infusion bags or bottles containing 100 mL or 250 mL of 0.9% sodium chloride and 5% dextrose respectively. Samples of drug solutions were collected at 0，1，3，24，48 hours and analyzed by HPLC methods RESULTS The remaining contents of insulin, isosorbide dinitrate, nitroglycerin and diazepam in 0.9% sodium chloride and/or 5% dextrose in PVC at 48 hours were 68.83% and 65.72%, 58.69% and 47.77%, 40.84% and 33.65% and 13.28%, respectively. The remaining contents of isosorbide dinitrate and nitroglycerin in G were 76.22% and 72.17%, 74.17% and 70.72%, respectively. No significant adsorption of the other drugs to the surface of G or NPVC was found (loss<7% and 8% respectively). Cefotaxime and cefradine were not stable in aqueous solutions CONCLUSION PVC and/or G should not be used with insulin, isosorbide dinitrate, nitroglycerin and diazepam. If there are no other choices, addition of extra drug to compensate for the losses is suggested.