Determination of ampicillinum natricum by means of p-CD-stabilized charge transfer spectrophotometry

PENG Xio-li;ZHO Ming;I Xio-hong

Chinese Pharmaceutical Journal ›› 2003, Vol. 38 ›› Issue (S1) : 11-13.

Chinese Pharmaceutical Journal ›› 2003, Vol. 38 ›› Issue (S1) : 11-13.
药品质量及检验

Determination of ampicillinum natricum by means of p-CD-stabilized charge transfer spectrophotometry

  • PENG Xiao-li,ZHAO Ming,BAI Xiao-hong
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Abstract

OBJECTIVE To siudv the specific absorpiivity and content of ampicillinum na-tricum compound ampicillinum na-tricum and sulbactan natricum for injection. MFITHODS B-CD-stabilized charge transfer spectrophotometry was used. RESULTS The specific absorptivity of charge transfer compound in B-CD was(124.0±5.8)%with RSD 2.8%,the linear range, the determi-nation limit and the rccoverv of anipicillinuni naLricum were 0.8-50,0.3mg·Land 99.4%respectively.CONCLUSION The stability of ampicillinum riaLricuni charge trarisfer compound in B-CD was more stable.As a precise. accurate, simple and speedy method, it may be applic for the determination of ampicillinum nalricum and sulbactam natricum for injec-tion.

Key words

anipicillinum natricum and sulbactam natricum for injection / ampicillinum natricum / charge transfer spectropho-tometry / B-cyclodextrin

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PENG Xio-li;ZHO Ming;I Xio-hong. Determination of ampicillinum natricum by means of p-CD-stabilized charge transfer spectrophotometry[J]. Chinese Pharmaceutical Journal, 2003, 38(S1): 11-13

References

[1]中国药典二部[S].2000;718.[2]沈敏.反相高效液相色谱法快速分析青霉素类抗生素[J].药物分析杂志,1991,11(2):93.[3]张琴,杨振华.氯唑西林栓剂含量测定方法的制定[J].山西医科大学学报,1998,29(1):29.

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