OBJECTIVE To synthesize a series of thermo sensitive gels,and determine their low critical solution temperatures (LCST).To screen the gels with LCST close to body temperature. METHODS Copolymers were synthesized by the method of free radical solution polymerization,then the study drug was carried with the polymers,and the drug release profiles was determined at different temperatures. RESULTS LCSTs of gels were increased by the method of copolymerization.Both the LCSTs and the properties of releasing drug of copolymers were different due to different synthetic conditions. CONCLUSION These gels can be used as pharmaceutical excipients for automatic controlled and sustained release preparations.
Key words
thermo sensitive gels /
lower critical solution temperature (LCST) /
copolymer /
pharmaceutical excipient
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Footnotes
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