OBJECTIVE To study the pharmacokinetic interaction after oral administration of doxofylline and moxifloxacin in rats.METHOD S After oral administration of doxofylline and moxifloxacin,the drug levels in plasma were measured by HPLC.The plasma concentration-time data were accessed by non-linear program (WINNOLIN) and the pharmacokinetic parameters were obtained.The interaction of the pharmacokinetics between doxofylline and moxifloxacine were evaluated by student-t test.RESULTS No significant difference was found on the pharmacokinetic parameters of doxofylline and moxifloxacine before and after co-administration.But the AUC of doxofylline's metabolite theophylline after co-administration was two times higher than single administration.CONCLUSION There was no obvious interaction of pharmacokinetics when doxofylline and moxifloxacin were co-administered.They can be taken simultaneously, but the concentration of theophylline in plasma should be monitored.
Key words
doxofylline /
moxifloxacin /
theophylline /
pharmacokinetics /
interaction
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Footnotes
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