Investigation on characteristics of Radix Puerariae isoflavones-drug carriers

GUO Jin-ping;SUN Qi-rong;YO Kng-de;ZHOU Qun;CHENG Guo-xing;GUO Hong-xi;

Chinese Pharmaceutical Journal ›› 2001, Vol. 36 ›› Issue (11) : 745-747.

Chinese Pharmaceutical Journal ›› 2001, Vol. 36 ›› Issue (11) : 745-747.
药剂

Investigation on characteristics of Radix Puerariae isoflavones-drug carriers

  • GUO Jian-ping1;SUN Qi-rong2;YAO Kang-de3;ZHOU Quan2;CHENG Guo-xiang3;GUO Hong-xia1;
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Abstract

OBJECTIVE To determine the characteristics of RP isoflavones in differens drug carrier system,including EC/PEG mixture carrier and PEG single carrier by solid dispersion technique.METHODS DSC,X-ray diffraction,IR-spectra and SEM were used.RESULTS By using solid dispersion technique,RP isoflavones was homogeneously dispersed in the drug carrier system.EC/PEG RP isoflavones solid dispersion formed a new type of material phase because of interaction between EC/PEG and RP isoflavones molecules.The PEG RP isoflavones solid dispersions formed more hydro-keys resulted by -OH in the molecules.After releasing 12 h,the EC/PEG RP isoflavones solid dispersion became much bigger,wider and soft than the material before releasing.CONCLUSION RP isoflavones was dispersed in molecular size in the carrier.PEG was the hole-making agent improving the permeability to EC-membrane,and EC had the function of dissolution and inflation.It demonstrated that EC/PEG RP isoflavones solid dispersion was an ideal drug release system,which released fast at initial and then following zero-order mechanism;PEG RP isoflavones solid dispersion was a fast release system.

Key words

RP isoflavones / drug carrier system / solid dispersion

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GUO Jin-ping;SUN Qi-rong;YO Kng-de;ZHOU Qun;CHENG Guo-xing;GUO Hong-xi;. Investigation on characteristics of Radix Puerariae isoflavones-drug carriers[J]. Chinese Pharmaceutical Journal, 2001, 36(11): 745-747

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