Actions of sodium dimercaptopropanesulfonate against convulsions induced by tetraethylenedisulfotetramine

ZHNG Chun-ying;ZHU Tong-jun;CHEN Xing-yn;HU Guo-xin;CHEN Zhi-kng;

Chinese Pharmaceutical Journal ›› 2001, Vol. 36 ›› Issue (11) : 736-738.

Chinese Pharmaceutical Journal ›› 2001, Vol. 36 ›› Issue (11) : 736-738.
药理

Actions of sodium dimercaptopropanesulfonate against convulsions induced by tetraethylenedisulfotetramine

  • ZHANG Chun-ying;ZHU Tong-jun;CHEN Xing-yan;HU Guo-xin;CHEN Zhi-kang;
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Abstract

OBJECTIVE To study the actions of sodium dimercaptopropanesulfonate(DMPS) against convulsions induced by tetraethylenedisulfotetramine(TET) in acutely poisoned animals.METHODS The 97% of convulsant dose(CD97) of TET poisoned mice were determined and the death number of TET poisoned rat was noted after ip administration of DMPS.The behavior of TET poisoned rabbits was observed after iv administration of DMPS.The behavior and electroencephalogram (EEG) of TET poisoned rats were observed after intracerebroventricular administration of traces of DMPS.RESULTS Peripheral administration of trace DMPS effectively inhibited tetanic convulsion and significantly elevated CD97 and reduced the death number in acutely poisoned animals.Central administration of trace DMPS also significantly inhibited convulsive seizure,reduced the death number and inhibited the emergence of tetanic convulsion wave on EEG.CONCLUSION DMPS showed the marked anticonvulsive actions on acutely TET poisoned animals.

Key words

dimercaptopropanesulfonate / tetraethylenedisulfotetramine / convulsion / anticonvulsion

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ZHNG Chun-ying;ZHU Tong-jun;CHEN Xing-yn;HU Guo-xin;CHEN Zhi-kng;. Actions of sodium dimercaptopropanesulfonate against convulsions induced by tetraethylenedisulfotetramine[J]. Chinese Pharmaceutical Journal, 2001, 36(11): 736-738

References

[1]耿文奎,梧永宁,冯向阳.广西平南县毒鼠强中毒的调查[J]. 广西预防医学,1998,4(2):86. [2]徐林发,莫文梅,刘建英.急性毒鼠强中毒71例分析[J].急诊医学,1998,7(4):232. [3]王乃硕,陈任强,孙宝凤.52例毒鼠强中毒调查报告[J].中国公共卫生, 1998,14(11):693. [4]黄韶清,赵德禄,关福玉,等.急性毒鼠强中毒161例报告[J].急诊医学,1997,6(4):202. [5]朱桐君,张春颖,陈醒言,等.巯基化合物对毒鼠强急性中毒小鼠的保护作用[J].温州医学院学报,2000,78(1):3. [6]徐端正编著.生物统计在药理学中的应用[M].北京:科学出版社,1986:304~307. [7]徐叔云,卞如濂,陈修主编.药理实验方法学[M].第2版,北京:人民卫生出版社,1991:162. [8]郝凤桐.毒鼠强急性中毒一例报告[J].中华劳动卫生职业病杂志.1992,10(1):34. [9]陈志康.沙蚕毒素系农药的毒理学和巯基化合物对急性中毒的特效解毒(Ⅱ)[J].药物流行病学杂志,1996;5(2):77. [10]Janaky R, Varga V, Oja SS,et al.Release of [3H]GABA evoked by glutamate agonists from hippocampal slices:effects of dithiothreitol and glutathione[J].Neurochem Int.1994,24:575.

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